Polymeric delivery systems for nucleic acid therapeutics: Approaching the clinic

Gene therapy using nucleic acids has many clinical applications for the treatment of diseases with a genetic origin as well development innovative vaccine formulations. Since in their free form are rapidly degraded by nucleases present extracellular matrices, have poor pharmacokinetics and hardly pass cellular membranes, carrier systems required. Suitable carriers that protect acid payload against enzymatic attack, prolong circulation time after systemic administration assist binding internalization needed to develop based drug products. Viral vectors been investigated also clinically used delivery vehicles. However, some major drawbacks associated use. Therefore there substantial attention on use non-viral cationic lipids polymers. This review focuses properties polymer-based formulations, referred polyplexes. Different polymeric summarized, barriers polyplexes encounter ways tackle these discussed. Finally is given status